Value of estrogen receptor β expression in normal colon mucosa and colorectalcancer: an immunohistochemical analysis

نویسندگان

  • Taha M.M. Hassan
  • Mohammed M. Mosaed
چکیده

Estrogens (ER) have a protective role against colorectal carcinoma (CRC). Reduction of death from CRC has been observed in women (30%) as compared to men (7%) in particular with the users of oral contraception and in those women treated with Hormone Replacement Therapy (HRT). The aim of this study is to analyze the expression of estrogen receptor β (ERβ) in normal colonic mucosa and in CRC. The archival material of formalin-fixed-paraffin embedded tissue sections of 10 cases of normal colonic mucosa and 25specimens of CRCwere utilized in this study. An immunohistochemistry using avidin-biotin immuno-enzymatic technique (ABT) for the expression of ERβ primary mouse monoclonal antibody was performed. ER is expressed in 3 out of 10 cases of normal colonic mucosa. CRC revealed different levels of ERβ expression regardless of patient age, gender, grade, invasion, or lymph node status. ERβpositive immunostaining is more common in well differentiated tumors and in lower stage of disease than in poor differentiated one and advanced stage of CRC. The immunopositivity of ERβ in CRC is seen in 56% of cases, whereas its negativity is 44%.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Estrogen Receptor Beta Expression in Melanomas Versus Dysplastic Nevi

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

متن کامل

Comparative Evaluation of Immunohistochemical Expression of Endothelin A Receptor between Oral Squamous Cell Carcinoma and Normal Oral Mucosa

Background: Recent research has provided evidences indicating the importance of endothelin axis in carcinogenesis. According to our knowledge, there are little information about endothelin A receptor (ETA) expression in oral squamous cell carcinoma (OSCC). So, the aim of the present study was to evaluate the immunohistochemical expression of ETA in OSCC and normal oral mucosa (...

متن کامل

Immunohistochemical Eexpression of Endothelin A Receptor in Dysplastic Oral Mucosa

Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM). Therefore, the aim of the present study was to evaluate immunohistochemical expression of ETA in DOM. Methods:</strong...

متن کامل

Comparison of the Expression Intensity of Estrogen Receptor Marker in Oral and Cutaneous Pemphigus Vulgaris

Background and aim: Pemphigus vulgaris (PV) is an autoimmune disorder that can clinically manifest as oral mucosal ulcers. Several researchers believe that the level of female sex hormones such as estrogen and progesterone could be effective in the pathogenesis and growth of lesions such as desquamative gingivitis. Studies related to oral ulcers have revealed contradictory results regarding the...

متن کامل

Clinicopathological significance of expression of Estrogen Receptor-Beta (ERβ), Progesterone Receptor(PR) and Vascular Endothelial Growth Factor-A (VEGF-A) in colorectal cancer

Background: Estrogen-receptor-beta (ER β), Progesterone-receptor (PR) and Vascularendothelial-growth-factor have been implicated to have a role in colorectal cancer. The expression of these markers and the clinicopathological significance of the same remain unclear. Purpose: The purpose of this study was to determine the expression of these biological markers: ERβ, PR and VEGF in colorectal can...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015